About D2D Cure
The Design2Data Program involves students in an investigation of the sequence-structure-function relationship of proteins. Using the lens of protein biochemistry, students expand their knowledge and develop skills by engaging in a research workflow representative of cutting-edge biotechnology training in high demand by employers.
A feature that makes D2D unique among other multi-institutional protein biochemistry CUREs is its connection to the protein modeling research community, RosettaCommons, which uses the student-generated data to improve functionally predictive enzyme-design algorithms.
Meet Our Enzymes
2JIE 2O9P 2O9R 2O9T 2Z1S
113,330 m−1 cm−1
β-glucosidase B (BglB, lovingly called “Bagel B” by our teams) is an enzyme that catalyzes the hydrolysis of glucose monosacharides from larger molecules at a β-glycosidic linkage. It is an essential enzyme for the degradation of cellulose by bacteria and fungi.
Our computational designs and kinetic measurements will utilize para-nitrophenyl-β-d-glucopyranose (pNPG) as a colorimetric reporter substrate.
Next EnzymeOur next enzyme system is coming soon.